If by game-based you mean video games, then you should definitely do a Mass Effect enf story. I've yet to find a single one, and this is a universe just ripe for enf situations, with so many characters to put in them (like FemShep, Aria T'Loak, etc.). Ultimately do what you want to do first and foremost, but if that just so happens to be a Mass Effect story, that would be most excellent.
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